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The keap1-nrf2 system: A thiol-based sensor-effector apparatus for maintaining redox homeostasis

Firth SM, Baxter RC

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019