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Dihydrofolate reductase (DHFR) which catalyzes the conversion of dihydrofolate into tetrahydrofolate, the active form of folic acid, is competitively inhibited by MTX and MTX-PGs, which depletes vital tetrahydrofolate (THF) needed for cellular functions (Xu et al

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Health Management Associates, 2015), more data are needed from other states using different integration models, including the Financial Alignment Initiative demonstrations

Although no significant clinical differences were observed in the overall cohort treated with NLY01 vs