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Eric Topol (39:48): Well, and to your point, there is not just the fact that you're getting this onward effect, at least we would deduce it's untoward, but that these people who are losing more than 10 pounds, losing 50 60, there's no way to get off these drugs that have been mapped out, whatever the effects are

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The intraperitoneal administration of LPS, which is a cell wall component of gram-negative bacteria, such as Escherichia coli and Salmonella spp, increases intestinal permeability and causes the accumulation of phosphorylated -synuclein fibrils in the intestinal mucosa and dorsal vagal nuclei 27