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Most antifungals in the pipeline also target either the fungal cell wall or the cell membrane (Fig

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In a joint 2014 letter, the agencies concluded that "A pooled analysis of data from 14,611 patients with type 2 diabetes from 25 clinical trials in the sitagliptin database provided no compelling evidence of an increased risk of pancreatitis or pancreatic cancer" and "Both agencies agree that assertions concerning a causal association between incretin-based drugs and pancreatitis or pancreatic cancer, as expressed recently in the scientific literature and in the media, are inconsistent with the current data

ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

Patients with type 2 diabetes require particular attention during discontinuation