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While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

However, the reason the distinction matters is for clarity and transparency

Yamakawa M, Wada K, Goto Y, Mizuta F, Koda S, Uji T, Nagata C

In this study, taurine ameliorated hyperglycemia and dyslipidemia by improving insulin resistance and decreasing leptin secretion in OLETF rats with long-term diabetes

Consequently, this format may be more marketable and thus likely to receive increased development interest and regulatory approval [13]