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Factors include: pH of gastrointestinal fluids Rate of gastric emptying and intestinal motility Presence or absence of food (which can enhance, delay, or reduce absorption), and Patient's age Disease states such as malabsorption syndromes (e.g., Crohn's disease) or liver disease can also profoundly affect bioavailability

Possible Risks and Adverse Reactions While generally safe, Vitamin B12 supplementation can lead to adverse reactions in some individuals

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