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It is noteworthy that recent research has indicated that GLP-1RAs can regulate salivary gland epithelial cells, which play an essential role in the development of SS

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3 Subtotal gastrectomy, once common before the availability of effective medical therapy for peptic ulcer disease, also can lead to vitamin B 12 deficiency by this mechanism

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This mechanism has been demonstrated in cardiovascular research, kidney disease studies, and liver inflammation models, and the same pathway is active in the pelvic environment