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Int J Endocrinol (2013) 2013:159858

doi: 10.1186/s12876-025-03954-4

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A longitudinal cohort study conducted from 2014 to 2017, involving 2,081 individuals aged 65 and above with annual follow-up intervals, revealed a significant reduction in depressive symptoms over time

Conversely, taxa enriched in PD, such as members of the Enterobacteriaceae family, Akkermansia, and Desulfovibrio, are associated with heightened lipopolysaccharide burden, mucin degradation, and increased generation of reactive oxygen species, collectively amplifying innate immune activation and pro-inflammatory cascades