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Excitatory G -subunits (G q or G 11 ) bind and activate phospholipase C- (PLC-), initiating a signaling cascade leading to the activation of protein kinase C (PKC) and the release of Ca 2+ from the ER

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The anabolic variety and redox status of GSH in the myocardium under pathological conditions When the heart is under stress from pathological factors, GSH redox homeostasis is disrupted, which is manifested by a significant decrease in GSH content and accumulation of GSSG in the myocardium