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Ganetespib acts as a radiosensitizer in pancreatic ductal adenocarcinoma by disrupting HIF-1, STAT3, and AKT signaling and inducing G2-M cell cycle arrest, thereby impairing DNA damage repair during irradiation

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It has been shown that abnormal increases in ROS levels in follicular fluid negatively correlate with oocyte development, embryonic development, and pregnancy outcome, and physiological ROS levels are required for normal oocyte development [Citation2528]