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A previous study showed that activation of GLP-1-producing NTS neurons that project to the VTA transiently reduced food intake in drug-nave mice 28

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Its the foundational skill for any serious researcher in this field

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A reduction in dose of oral hypoglycemic medication (e.g., sulfonylureas) or insulin may be required in some patients [see Clinical Studies (14)]

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It was not clear why -cell GLP-1 sensitivity did not improve in response to sitagliptin in that study

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