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[27] Opioid-induced constipation Clinical features Recent initiation of an opioid or dose adjustment New or worsening constipation Fecal impaction may be present Physical examination typically normal Diagnostics [8] Clinical diagnosis Rome IV diagnostic criteria for OIC Recent initiation of opioid treatment or a dose increase AND 2 of the characteristic clinical features of functional constipation: Passage of spontaneous bowel movement 20% of the markers are retained

The extended titration schedule helps minimize gastrointestinal adverse effects such as nausea, vomiting, and diarrhea, which are the most common reasons for treatment discontinuation

Researchers should exercise extreme caution and prioritize foundational studies to build an evidence base for such combinations

A wide variety of Paleo-friendly foods contain glutathione