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[7] In a Bayesian network meta-analysis of 48 randomized trials and nearly 28,000 participants, the dominant gastrointestinal events were nausea (about 21.5%), diarrhea (10.6%), vomiting (9.1%), and constipation (7.9%), with semaglutide carrying one of the highest constipation risks

204,205 Both thiol availability and redox status have been shown to influence the expression of cystinosin, and a shift towards a more oxidised status of cysteine and glutathione with a progressive increase in the mRNA levels of cystinosin has been reported

Further study is warranted to elucidate any causal association.

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Ultimately, interdisciplinary collaboration among researchers, clinicians, and pharmaceutical industries is crucial for translating these insights into safe, effective, and accessible obesity treatments