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The efficacy of saxagliptin as add-on therapy with metformin was evaluated in 743 patients with an A1C between 7% and 10% for a 24-week period, compared to metformin alone

Physical activity contributes significantly to total energy expenditure, which is determined by three primary components: basal metabolic rate, the thermic effect of foodalso referred to as dietary-induced thermogenesisand the energy utilized during physical activity [60, 61]

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For example, vitamin B12 injections may lead to skin changes, such as acne and dermatitis (rash)