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Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis

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Tryptophan oxidation is the degradation route most commonly detected by RP-HPLC in stored melanocortin analogues, with tyrosine at position 2 and histidine at position 6 secondary sites of concern, and freeze-thaw cycling accelerates both aggregation and oxidative degradation