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Mouse husbandry For the isolation of mitochondria and proximal tubular cells, kidneys were excised from cadavers of 812-week-old male and female wild type C57/BJ and C57/BJ crossed with 129S6 used for other experimental purposes not related to this study, following the principles of the 3Rs (Replacement, Reduction and Refinement) of animal experimentation

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Control mice were instilled with 50 l of saline

LitKDm 2 study: the impact of health literacy and knowledge about the disease on the metabolic control of type 2 diabetes mellitus

Suffers of the serious genetic condition phenylketonuria (PKU) are unable to convert phenylalanine to tyrosine, whilst patients with alkaptonuria have a defective tyrosine metabolism, producing distinctive urine which darkens when exposed to the air