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Liver health is a primary concern

Supplementing with vitamin C has not been found to be toxic, but taking more than 2,000 mg per day may cause abdominal cramps, diarrhea and nausea, as well as increase the risk of developing oxalate kidney stones in men ( Additionally, doses over 250 mg per day may interfere with tests designed to detect blood in the stool or stomach and should be discontinued two weeks before testing ( Summary Fresh fruits and vegetables are excellent sources of vitamin C and should prevent deficiency when consumed on a daily basis

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This does not establish clinically meaningful whole-body telomere lengthening in people

GLP-1 receptor agonists were compared to nonuse of GLP-1 receptor agonists in a cohort of 95,490 people (mean age, 50.6 years)