A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)
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I would likely have experienced neurological damage with that treatment
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A 2021 review of NNMT as a metabolic target stated plainly that clinical trials targeting NNMT have not been reported until now (Liu 2021, PMID 34368359) [5], and that held into 2026