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For patients with PCOS, long-term use of metformin may cause adverse reactions, and its safety still needs to be further evaluated

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It means there are multiple entry points for supporting brain repair, and the right approach depends on the specific situation, whether acute injury, chronic degeneration, or proactive neuroprotection

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271,272 Additionally, hyperglycemia-induced oxidative and nitrosative stress activates poly(ADP-ribose) polymerase (PARP), a nuclear enzyme involved in DNA repair