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The Gsto2 upregulation was also confirmed by western blot analysis (Fig

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doi: 10.1001/jamapsychiatry.2019.1694 207

Part of this migratory effect can be attributed to the stimulation of IL-1 secretion by resident macrophages via MSU crystals, which subsequently instigates caspase-11 expression in macrophages through IL-1R and MYD88 ( sUA triggers macrophage migration indirectly

(PubMed) Zuin M, Cervellati C, Brombo G, Trentini A, Roncon L, Zuliani G