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However, such a compensatory effect at the BDNF protein level did not occur in the rat hippocampus, when BSO and GBR 12909 were administered in combination (37)

When used in conjunction with other peptides like Melanotan II or Epithalon, DSIP could enhance the effects of sleep-inducing nasal sprays, making them more effective at inducing deep sleep and improving overall sleep quality

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While repurposing of metformin is being expanded to include a variety of pathophysiological disorders due to its pleiotropic modes of action (Foretz et al., 2023a), we aim to specifically examine the current knowledge on metformin-microbiota connection and its associated synergistic and/or detrimental effects in T2D individuals

For the preparation of all solutions, double distilled water was used