Physiologically occurring cell death, referred to as programmed cell death (PCD), is essential for appropriate embryonic development of multicellular organisms as well as for tissue remodeling during adulthood [1]
In experiments using melatonin, either melatonin (10mg/kg, Sigma) or an equivalent volume of DMSO (Sigma) was intraperitoneally injected each day for three days at 17:00, immediately after intranasal challenges had been performed
Importantly, therapeutic strategies should target not only the source of initiation and/or progression of the disease but also self-amplifying mechanisms that sustain emphysema themselves, namely airspace enlargement, ECM breakdown, and progressive mechanical failure, all of which should hinder the self-perpetuation of tissue damage and stabilize lung architecture
10.1111/j.1365-2982.2010.01664.x 94 CuiL.LiS.WangS.WuX.LiuY.YuW.et al
Geng N, Shi B-J, Li S-L, Zhong Z-Y, Li Y-C, Xua W-L, et al