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High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]
Proteins 75 , 187205 (2009)
Mechanism: VEGF upregulation drives new blood vessel formation around damaged joints
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Overall, this may lead to decreased adipose tissue and net energy consumption (i.e
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