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The coupling of A-GSH targeting ligands resulted in significantly higher BBB penetrations for the 3-PLG-dopa-A-GSH nanocarriers both in the presence of organoids from healthy (3-PLG-dopa-A-GSH P app : 6.52 10 6 cm/s) and PD cells (3-PLG-dopa-A-GSH P app : 6.80 10 6 cm/s) compared to the permeability values of non-targeted formulations

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The presence of copper is necessary for the biological activity of the complex observed in in vitro studies

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