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Trial checkpoints: end of course, then 30-90 day follow-up
In addition, the remaining membrane-bound TNF fragment is further cleaved by the intramembrane protease signal peptide peptidase-like 2b (SPPL2b), whereupon the intracellular domain of TNF (ICD-TNF) is released, leading to the activation of the interleukin-1 (IL-1) promoter (122, 123)
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Understanding these mechanisms is essential for implementing appropriate protective strategies during GLP-1 treatment
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