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Magnesium Boosts enzyme functions, bone health, calcium absorption, carbohydrate and glucose metabolism, heart health, relieving anxiety and headaches

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Metformin further enhances oxidative stress resistance via upregulation of Klotho and GDF-15, promoting mitochondrial efficiency and anti-senescence signaling (Zhang et al., 2012)

Luo C, Xu W, Tang X, Liu X, Cheng Y, Wu Y, Xie Z, Wu X, He X, Wang Q, Xiao Y, Qiu X, Tang Z, Shao G, Tu X (2022) Canonical wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation