GLP-1RAs and SGLT2is act through distinct and complementary mechanisms of action to exert glycemic control and cardiovascular benefits [4, 9]
Treatment remains symptomatic, focusing on administering levothyroxine (LT4) supplementation to correct hypothyroidism as needed (5)
Weeks 1-4: 0.25 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 5-8: 0.5 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 9-12: 1.0 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 13-16: 1.7 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Week 17 and beyond: 2.4 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Some providers modify this schedule based on individual tolerance
Systemic inflammation drives neuroinflammation
Your monthly cost includes doctor oversight, lab monitoring (metabolic panel, liver function, kidney function, lipids, thyroid), and protocol adjustments based on how your body responds