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Interestingly, induction of R175H alone in the absence of APR-246 did not significantly repress xCT expression (Supplementary Fig

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This pathway is a fundamental regulator of cellular processes such as cell fate decisions, embryonic development, tissue repair and cancer (Siebel and Lendahl, 2017)

The risk here isnt really the medications themselves when properly prescribed, its sourcing them from unregulated suppliers