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Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis

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By acting as a crucial cofactor for the pyruvate dehydrogenase complex, ALA ensures that the glucose transported into the cell (a process enhanced by berberine) can be efficiently converted into acetyl-CoA and fed into the Krebs cycle

Notably, GLS-mediated deamination of glutamine to glutamate is the first and rate-limiting step of glutaminolysis, making it an attractive druggable target 9