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The risk of lean mass loss during rapid weight reduction on tirzepatide is a particular concern for autoimmune patients who may already have muscle wasting from disease activity, corticosteroid use, or reduced physical activity during flares

Tripeptide-Copper Complex GHK-Cu Stimulates Collagen Production and Elastin Repair in Cultured Human Dermal Fibroblasts

Cortisol is a stress hormone, and while a transient increase might not be problematic, sustained high levels can have metabolic consequences

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This suggests that substantial unintentional weight loss in placebo patients likely reflected underlying health problemssuch as cancer, heart failure, or other serious conditionsrather than therapeutic benefit