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Documented Long-Term Side Effects of Corticosteroids Bone loss and fractures due to calcium and vitamin D depletion and impaired osteoblast activity (2) Blood sugar dysregulation and steroid-induced diabetes through increased insulin resistance and gluconeogenesis (3) Muscle wasting and impaired connective tissue repair from protein catabolism and suppressed synthesis (4) Weakened immunity, delayed healing, and prolonged infections related to micronutrient depletion and immune suppression (5) Weight gain, mood changes, and insomnia driven by hormonal and circadian disruption (6,7) Abnormal blood lipids, hypertension, and increased cardiovascular risk , including heart attack, with long-term use (8) Thinning skin and easy bruising from collagen breakdown and connective tissue loss (9) Psychiatric effects , including anxiety, irritability, depression, andin severe casessteroid-induced psychosis, particularly at higher doses or with prolonged exposure (10) Even short-term corticosteroid use can cause side effects in susceptible patients

In a world where health supplements are plentiful, glutathione stands out for its numerous benefits

It targets the GLP-1 receptor exclusively, producing average weight loss of 15 to 17 percent of body weight over 68 weeks in clinical trials

L-carnitine is a vital bioactive compound involved in energy metabolism, playing a key role in transporting fatty acids to the mitochondria for conversion into energy

doi: 10.1016/j.etap.2024.104391 24 SallissMEFarlandLVMahnertNDHerbst-KralovetzMM