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Because it promotes detoxification and alters cellular signaling, some individuals may experience a temporary exacerbation of symptomsoften colloquially referred to as a 'Herxheimer reaction' or detox flareas toxins are mobilized for excretion

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Using a variety of experimental models, glucose sensing and amino acid signalling in pancreatic islets were shown to play a fundamental role in glucagon secretion [12]

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