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Depicts MTHFR variant activity For example, an individual who is heterozygous at both C677T (C/T) and A1298C (A/C), known as a compound heterozygote, is expected to exhibit a 55% decrease in MTHFR enzymatic activity (35% activity due to the presence of one T allele at C677T and 20% activity due to the presence of one C allele at A1298C = 55%)

Front Pharmacol 12:681417 Datta A, Kim GA, Taylor JM, Gugino SF, Farrow KN, Schumacker PT, Berkelhamer SK (2015) Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent