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All three RALDH are expressed in tissue specific and developmental stage specific patterns

One concern exists

The role of glia in the peripheral and central auditory system following noise overexposure: contribution of TNF- and IL-1 to the pathogenesis of hearing loss

patens is strongly down-regulated by the addition of H 2 O 2 , salt, salicylic acid, and atrazine (Liu et al., 2013), whereas poplar DHAR2 , in contrast to poplar DHAR3 , is up-regulated in shoots but not in roots in response to H 2 O 2 , atrazine and to a lesser extent CDNB (Lan et al., 2009)

Interesting it got approved under the National Priority Voucher pilot, that could speed rollout