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The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

Its adverse effects are well documented, and DEET has been shown to have cytotoxic and apoptotic properties in nucleated cells

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Onset Time 7 days, estimated optimal impacts after 3-4 weeks of regular use

Wang S, Qiao H, Wang P, Wang Y, Qin D (2021) ZDHHC19 is dispensable for spermatogenesis, but is essential for sperm functions in mice