Yet depriving your body of vital nutrients like glutathione can leave you feeling sluggish, dull-minded and vulnerable to infections
J Cell Biochem 119(1):157184 Rizwan M, Ali S, Abbas F, Adrees M, Zia-ur-Rehman M, Farid M et al (2017) Role of organic and inorganic amendments in alleviating heavy metal stress in oil seed crops

Support Glutathione Recycling with Micronutrients Making and recycling glutathione requires specific vitamins and minerals: Vitamin C helps regenerate used glutathione Vitamin E works in tandem with glutathione to combat oxidative stress B vitamins (especially B6, B12, and folate) support Read more in the comments below Continuation methylation, which influences glutathione metabolism Selenium is a cofactor for glutathione peroxidase, a key enzyme Magnesium and zinc also support glutathione enzyme activity Avoid What Depletes It To preserve your glutathione, reduce the burden on your antioxidant system: Limit excess alcohol Avoid smoking or secondhand smoke Minimize exposure to heavy metals and pollutants Reduce chronic stress, which increases free radical production Get adequate sleep, when your body restores antioxidant systems Bottom Line You dont need a supplement to support glutathione
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Interestingly, a small trial in 30 premenopausal women found that daily multivitamin supplementation for ten weeks did not improve overall mood, but when the supplement also contained 7 mg/day of zinc (RDA=8 mg/day), the authors noted significant improvements in two components of POMS: the anger-hostility and the depression-dejection scores (140)