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In skin, it binds to fibroblast receptors and switches on the genes responsible for Collagen I, Collagen III, and elastin while calming the inflammatory signaling that accelerates aging

Hydrated skin is essential for collagen and elastin, or for keeping skin plump

Dehydration: Lack of hydration can result in dry, chapped lips that may appear darker

Research indicates that TGF-1 modulates renal injury by stimulating downstream Smads, where Smad3 is a key mediator that promotes renal fibrosis, Smad2, and Smad7 have renal protective effects, and Smad4 exhibits both promotion of fibrosis and inhibition of inflammation through different mechanisms (191)