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Autophagy is a highly dynamic, multistep process involving the degradation of cytoplasmic cargo through the lysosomal machinery 51 and serves as a protective response mechanism under oxidative stress 52

PLoS ONE 15 , e0233439 (2020)

To determine whether inflammation-mediated NAD + depletion had any effect on mitochondrial function in this model, an XFe96 Seahorse assay was conducted to measure mitochondrial oxygen consumption rates (OCRs) (46)

However, the underlying mechanisms of pancreatic islet fibrosis and -cell failure remain unclear

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