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GHK-Cu also downregulates pro-inflammatory cytokines like TNF-alpha and IL-6, reduces levels of fibrinogen (involved in inflammation), and blocks NF-kB and p38 MAPK activation

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For very high disease activity, you may even go right to an IL-17 blocker and bypass anti-TNFs, which have not proven as effective for ankylosing spondylitis as they have been for other types of inflammatory arthritis

Choose a Ratio that Works for You: The best ratio is the one that simplifies your research protocol

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