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Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise

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It has been suggested that hyperthyroidism acts as a hormonal trigger for the activation of nuclear factor kappa, transcription factor involved in the regulation of pro-inflammatory cytokines TNF- and IL-6 85,86