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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

This illusion stems from the successful skin tightening results delivered by the Thermage procedure

The researchers did not observe a corresponding reduction in food intake during that short experiment

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