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This work enhances the interpretability of vMRI measures, advances understanding of HD progression, and supports the use of vMRI as an imaging biomarker for drug development Other authorsSee publication Safety and Efficacy of Flexible-dose Deutetrabenazine in Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial (ARTISTS 1) JAMA Open Network In this randomized, double-blind, placebo-controlled study of deutetrabenazine in children and adolescents with Tourette syndrome, the primary efficacy end point was not met