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The same group also found that -CBT-diol has the antiproliferative, anti-migratory and anti-invasive effects against multiple breast cancer cell lines which the c-Met overexpressing MDA-MB-231 breast cancer cells are the most sensitive, indicating that -CBT-diol may be a novel c-Met inhibitors for the c-Met dependent malignancies therapy ( In liver cancer, -CBT-diol inhibited the proliferation of HepG2, SMMC-7721 and HL-7702 tumor cells, reduced the formation of carcinoma cell clones, disrupted the cell cycle by significantly increasing S phase, induced cell apoptosis by regulating p53-PUMA, PI3K-Akt, and IL-1-NF-B-IAP pathways (Yuan et al., 2019)

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Long-Term Effects of Smoking Cigarette smoking is a major cause of preventable death around the world