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In addition to short stature, the developmental delay and cognitive disability are typical features which tend to worsen over time, leading to an autism-like phenotype, including self-mutilation behaviors, skin picking, learning problems, irritability, and compulsive behaviors [26]

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T.LefortM.Mndez-DvilaC.ArgenteJ.et al (2007)

Dosing strategy: Started at 600 mg twice daily and increased to 1200 mg twice daily