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Driver: Expanding manufacturing capacity Restraint: Stringent cost and payer controls Opportunity: Increasing studies on oral GLP-1 Challenge: Counterfeits and compounded GLP-1 gray market

Participants in Phase 2 trials showed significant reductions in fasting glucose, HbA1c, triglycerides, blood pressure, and waist circumference

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See Additional file 1 for a description of the data normalization procedures and statistical analyses used to generate gene sets and/or ranked gene lists for each of the previously published gene-expression datasets