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Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction
The recommended starting minimum dosage is 5 mg/kg 3 times a day
Renal medullary blood flow is decreased in SS rats within a few days after the start of a high-salt diet 59,60
More receptors means more weight loss: 28.7% for retatrutide vs 22.5% for tirzepatide in trials, but also more side effects
