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While transdermal patch technology has advanced, injectable GLP-1 agonists remain the clinical gold standard because they achieve therapeutic blood levels that patches cannot consistently match

[58] A June 2025 study suggests that the difference may be attributable to the AS01 adjuvant used in Shingrix as the AS01-containing RSV vaccine (Arexvy) shows a very similar reduction in dementia risks

According to the authors, though, these latter studies have largely relied on self-reported surveys of GLP-1 users, which can be subject to several issues (people arent great at remembering even their recent meals, for one)

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