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However, the lack of peer-reviewed clinical data and regulatory approval raises questions about its long-term safety and effectiveness

Anal Chem 56:18901898 Kelly CP, Cramer CJ, Truhlar DG (2006) Aqueous solvation free energies of ions and ion-water clusters based on an accurate value for the absolute aqueous solvation free energy of the proton

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The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense