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GLP-1 receptor agonists are not appropriate in certain situations, including: Personal or family history of medullary thyroid carcinoma (MTC) History of multiple endocrine neoplasia syndrome type 2 (MEN2) Pregnancy or breastfeeding Known hypersensitivity to the medication History of pancreatitis (relative contraindication

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If red spots appear with fever, stiff neck, confusion, severe headache, breathing trouble, or rapid worsening, seek urgent medical help

321 For HCM, epigenetic editing can selectively silence mutant alleles while sparing wild-type copies or activate compensatory pathways without permanent genetic changes

If the findings cannot be replicated, the picture changes